Selank is a synthetic heptapeptide; it is also known as an anxiolytic nootropic. It’s an analog of the endogenous immunomodulatory peptide Tuftsin, which is modified for stability and CNS activity. It is a synthetic heptapeptide consisting of seven amino acids; the Pro-Gly-Pro tail was added to Tuftsin to resist enzymatic breakdown and improve blood-brain barrier penetration. Selank calms anxiety by boosting GABA-A signaling and serotonin while blocking enzymes that break down natural opioids. It also raises BDNF and balances stress hormones, giving anxiety and cognitive benefits without sedation or dependence.
Key Features
| About | |
| Drug Class | Anxiolytic, Nootropics |
| Subclass | Synthetic regulatory peptide |
| Active ingredient | Selank |
| Selank | |
| Composition | Active ingredients
Selank Inactive ingredients: Methylparaben Purified water |
| Packaging Type | Sterile glass vial with dropper cap |
| Pack Size | 1 vial |
| Dosage | 5 mg and 10 mg |
| Active ingredients | Selank |
| Shelf Life | Two years refrigerated for unopened vials. |
| Usages | Anxiety Disorder, Neurasthenia, Asthenic conditions, Prophylaxis |
How does Selank Work?
- GABAergic modulation: Allosterically enhances GABA-A receptors. Increases inhibitory tone and increase anxiolytic effect without sedation.
- Serotonin system: Modulates 5-HT metabolism, Increases serotonin in brain stem, hippocampus. Decreases serotonin breakdown.
- Enkephalin stabilization: Inhibits enzymes that degrade enkephalins. That may increase endogenous opioid peptides that lead analgesia, mood effects.
- BDNF upregulation: Increases brain-derived neurotrophic factor mRNA in hippocampus lead neuroplasticity, cognition.
- Immunomodulation: Tuftsin-like effects. Modulates IL-6 expression, T-cell balance. Anti-inflammatory in stress models.
- Norepinephrine: Modulates NE release in locus coeruleus. Balances arousal/anxiety.
- Nootropic angle: Enhances memory consolidation in rats. Increases theta rhythm in EEG.
Research Application
Selank is used in dealing with:
- Anxiety scores.
- Increase memory consolidation, attention, and also prevents stress-induce d deficits.
- Increase serotonin and decrease anhedonia behaviour.
Strengths
- Selank 5 mg
- Selank 10 mg
Side effects and Interaction
The common side effects that can be seen in Selank can be transient headache, slight BP changes, allergic rhinitis and skin rash. CNS depressant GABA drugs like benzos, alcohol, barbiturates. SSRIs and SNRIs both modulate serotonin, additive risk of serotonin syndrome.
Pharmacokinetics
- Tmax it may reach 30-60 sec brain and 2-5 min in blood.
- Half life is about 2-3 min plasma.
Selank is with very short half-life. These effects outlast plasma presence due to receptor/ Brain-derived Neurotrophic factor (BDNF) changes. Intranasal bypasses first-pass hits brain fast via olfactory trigeminal route.
Product Specification
| Specification | |
| Peptide class | Synthetic Regulatory Heptapeptide |
| Molecular structure | Thr–Lys–Pro–Arg–Pro–Gly–Pro |
| Purity (HPLC) | ≥ 99% |
| Appearance | White to off-white fluffy powder |
| Reconstitution | Sterile bacteriostatic water or 0.9% NaCl solution |
| Solubility | Freely soluble in water (up to 50 mg/mL). |
| Storage (lyophilized) | −20°C, protected from light and moisture |
| Storage (reconstituted) | 2–8°C, use within 28 days |
Precautions
- Serotonin/ NE modulation could trigger mania so it should be avoided.
- GABA-A modulation effects on seizure.
- In Liver and Kidney disease, rapidly degraded by peptidase.
- This may interact with SSRIs, MAOIs, benzos due to overlapping GABA/serotonin pathways.
- Reconstituted peptides must be sterile.
- Pregnant and lactating should avoid.
Conclusion
Selank is a synthetic heptapeptide it is also known to be as an anxiolytic nootropic. It’s an analog of the endogenous immunomodulatory peptide Tuftsin, which is modified for stability and CNS activity. It is a 7 Aminoacid structure, the Pro-Gly-Pro tail was added to Tuftsin to resist enzymatic breakdown and improve blood-brain barrier penetration. Selank Prptide is stable peptide designed for rapid anxiety relief and cognitive benefits without benzo drawbacks. It may show some side effects mild nasal irritation, transient headache, slight BP changes, allergic rhinitis and skin rash. This is only for Research purpose it is not for human consumption, veterinary use or therapeutic application or any diagnostic purpose.
Related Research Peptides
You may also explore TB 500, Semax 10 mg, Tesamorelin + Ipamorelin 8mg Blend, and GLP-TZ peptides available at Zycare Peptides.
FAQs
What is Selank?
Selank is a synthetic heptapeptide an Anxiolytic-nootropic peptide, not a benzo, it is a lab modified version of a natural immune peptide called Tuftsin.
What for Selank is used?
Selank is used in anxiety disorder, neurasthenia, adjustment disorder and asthenic conditions.
What can be the possible side effects of Selank?
The possible side effects of Selank can be transient headache, slight BP changes, allergic rhinitis and skin rash.
How fast does Selank work?
The onset of action is 5-20 minutes intranasal. It may reach peal approx. 30-60 minutes.
How to store Selank?
It can be stored lyophilized powder, 2-8°C, for 2 years keep it dry/ dark. Reconstituted 2-8°C, use within 7-14 days. Don’t freeze.
| Note: Selank is only for Research purpose it is not for human consumption, veterinary use or therapeutic application or any diagnostic purpose. |
Liam G. –
Selank has been simple to incorporate into my daily routine. The product quality and consistency have been excellent.
Casey Mary –
Very satisfied with this purchase. The ordering process was easy and the product met my expectations.