Tesamorelin CJC-1295 Ipamorelin 12mg Blend are the research peptide and is triple peptide stack designed to stimulate growth hormone release through two complementary pathways Growth hormone releasing hormone (GHRH), growth hormone releasing peptide (GHRP). Tesamorelin and CJC 1295 both binds to GHRH receptor on pituitary somatotropin and may increase cAMP and leads to GH synthesis and release. Ipamorelin binds ghrelin receptor as different pathway using intracellular Ca2+ lead to GH release and may blocks somatostatin.
Key Features
| About | |
| Drug Class | Growth Hormone Secretagogue (GHS) |
| Subclass | Growth hormone secretagogue peptides |
| Active ingredient | Tesamorelin, CJC-1295 and Ipamorelin |
| Tesamorelin CJC-1295 Ipamorelin 12mg | |
| Composition | Active ingredients
Tesamorelin CJC-1295 Ipamorelin Inactive ingredients: Lyophilized powder Bacteriostatic water |
| Packaging Type | Type 1 Borosilicate glass vial |
| Pack Size | 1 vial |
| Dosage | 12 mg |
| Active ingredients | Tesamorelin, CJC-1295 and Ipamorelin |
| Shelf Life | 2-3 years if sealed |
| Usages | Healing and Repair |
How does Tesamorelin CJC-1295 Ipamorelin 12mg work?
- Tesamorelin GHRH (Growth Hormone releasing Hormone) receptor Pulsatile GH (Growth hormone) release, mimics natural GHRH approx. 38 min.
- CJC-1295 no DAC GHRH receptor Pulsatile growth hormone release, short acting approx. 30 min
- Ipamorelin GHS-R1a ghrelin receptor Triggers growth hormone and also inhibits somatostatin approx. 2 hrs
Combined effect of Tesamorelin CJC-1295 Ipamorelin 12mg
- GHRH analogues increase cAMP, growth hormone gene transcription + release.
- Ipamorelin increases intracellular Ca2+, growth hormone vesicle exocytosis and also blocks somatostatin, which normally shuts GH off.
- Result: Higher amplitude GH pulse vs monotherapy, with IGF-1 elevation 12–24 hrs later.
Because all 3 are short-acting, the blend creates 1-3 sharp GH pulses per day depending on dosing, not a continuous ‘GH bleed’ like CJC-1295 DAC.
Research Application
- Recovery and Healing.
- Anti-aging and Longevity.
- Sleep Quality
- GH deficiency, body composition, visceral fat, injury recovery, sleep
- Anecdotal research uses i.e., Fat loss, lean mass support, recovery, anti-aging clinics
Research Dosage
- It is available in 12 mg vials.
- If your CJC-1295 has DAC its long acting it can be taken weekly.
Side effects
Water retention, Edema, carpal tunnel symptoms, Tingling numbness in hands/feet, Joint pain, myalgia, Headache, flushing, Injection site redness lumps, Mild hunger from Ipamorelin, Lethargy after dose are some common side effects of Tesamorelin CJC-1295 Ipamorelin 12mg. It may show some interactions like insulin or oral hypoglycemics, GH raises blood sugar may need dose adjustment. Monitor glucose. Corticosteroids, Prednisone blunts GH response. Thyroid hormone, GH can unmask central hypothyroidism. Check Thyroid stimulating hormone, free T4/T3. Oral estrogen reduces IGF-1 response to GH. Somatostatin analogues, Octreotide directly blocks effect. Other GH secretagogues: MK-677, GHRP-2, GHRP-6 this led to excessive GH/IGF-1, and increase the risk of side effects.
Pharmacokinetics
- Absorption: It may reach the peak plasma concentration, Tmax 15-40 min.
- Half-life of Tesamorelin is approx. 38 min, CJC-1295 in no DAC is 30 min, and Ipamorelin approx. 2 hrs.
- GH pulse it may Starts within 10-20 min post-injection, peaks and reach peak at approx. 30 min, returns to baseline by 3 hrs.
- IGF-1: Rises 12–24 hrs later, stays elevated approx. 24 hrs. Daily dosing gives sustained IGF-1 without 24/7 GH elevation.
- Metabolism: Cleaved by proteases. No CYP450 interaction.
- Excretion through Renal.
Product Specialization
| Specification | |
| Peptide class | Tesamorelin: GHRH analogue, 44-AA modified GRF (1-44).
CJC-1295 no DAC: GHRH analogue, 30-AA modified GRF (1-29) with drug affinity complex removed. Ipamorelin: GHRP, pentapeptide ghrelin mimetic. |
| Molecular Structure | Tesamorelin 44 Amino acids, CJC-1295 29 Amino acid, Ipamorelin 5 Amino acid. |
| Purity (HPLC) | ≥ 99% |
| Appearance | White to off-white amorphous powder or cake. |
| Reconstitution | Use sterile water or bacteriostatic water. |
| Solubility | Soluble in water greater than or equal to 1, 5, 2 mg/mL respectively. Also, soluble but DMSO isn’t used for injection due to tissue irritation. |
| Storage (lyophilized) | -20°C, in sealed vial desiccated. |
| Storage (reconstituted) | 2-8°C, for 1-2 years |
Precautions
- In the prior Active malignancy or history of cancer, diabetic retinopathy, uncontrolled diabetes, severe respiratory disease, sleep apnea, intracranial hypertension it should be avoided.
- In the Pregnancy, breastfeeding it should be avoided.
- In active pituitary tumour it should be avoided.
Conclusion
Tesamorelin CJC-1295 Ipamorelin 12mg are the research chemicals and is triple peptide stack designed to stimulate growth hormone release through two complementary pathways Growth hormone releasing hormone (GHRH), growth hormone releasing peptide (GHRP). Tesamorelin and CJC 1295 both binds to GHRH receptor on pituitary somatotropin and may increase cAMP and leads to GH synthesis and release. Ipamorelin binds ghrelin receptor as different pathway using intracellular Ca2+ lead to GH release and may blocks somatostatin. It may show some side effects like Edema, carpal tunnel symptoms, Tingling numbness in hands/feet, Joint pain, myalgia, Headache, flushing, Injection site redness lumps, Mild hunger from Ipamorelin, Lethargy. It is only used as a research peptide.
Related Research Peptides
You may also explore Tesamorelin + Ipamorelin 8mg, Selank, GLP-RT, and Tesamorelin peptides available at Zycare Peptides.
FAQs
What is Tesamorelin CJC-1295 Ipamorelin 12mg?
Tesamorelin CJC-1295 Ipamorelin 12mg are the research chemicals and is triple peptide stack designed to stimulate growth hormone release.
How does Tesamorelin works?
It may bind to GHRH receptor on pituitary somatotropin and may increase cAMP and leads to GH synthesis and release.
What can be the possible side effects of Tesamorelin CJC-1295 Ipamorelin 12mg?
The possible side effects of Tesamorelin CJC Ipamorelin can be Edema, carpal tunnel symptoms, Tingling numbness in hands/feet, Joint pain, myalgia, Headache, flushing, Injection site redness lumps.
What for the blend Tesamorelin CJC-1295 Ipamorelin 12 mg is used?
The blend of Tesamorelin CJC-1295 Ipamorelin 12mg can be used in recovery, healing, anti-aging, longevity, sleep quality, metabolic studies etc.
What is Growth hormone releasing peptide?
Growth hormone releasing peptide is a class of synthetic peptides that may trigger GH release by mimicking ghrelin.
Henry F. –
Everything arrived as expected, and the product has been easy to use. A very positive experience from start to finish.